Development of fully automatic technique to generate parametric images of myocardial blood flow with15O-water and positron emission tomography using basis function method

Hiroshi Watabe, Kazuhiro Koshino, Noboru Teramoto, Youichiro Ohta, Takuya Hayashi, Hidehiro Iida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Regional myocardial blood flow (MBF) can be measured with ISO-water and PET using the one-tissue compartment model (IT model) with perfusable tissue fraction (PTF), which provides MBF value that is free from the partial volume effect (PVE). Study with ISO-water has several advantages such as the ability of repeated scan. However, the image quality of ISO-water is limited, which impedes the computation of MBF and PTF values at the voxel level. We implemented the basis function method (BFM) for generating parametric images of MBF, PTF and arterial blood volume (Va) with ISO-water and PET. The BFM is to linearize the solution of IT model, which results in a computationally much faster method than the conventional non-linear least squares fitting method (NLM) in estimating the parameters. In order to fully automate the process of the BFM, PET images were realigned to a reference image using Affine transformation. Arterial input function with PVE correction was derived from the realigned PET images using templates of regions of left ventricle and myocardium. In order to validate the BFM, series of PET studies were performed on infarction model pigs (n=4). PET scans with ISO-water were performed with varying doses of adenosine (5-7 scans for each pig). The results by the BFM were well correlated to ones by the NLM.The method automatically generated functional maps computationally fast enough for clinical application.

Original languageEnglish
Title of host publication2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages2256-2258
Number of pages3
DOIs
Publication statusPublished - 2005 Dec 1
Externally publishedYes
EventNuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico
Duration: 2005 Oct 232005 Oct 29

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume4
ISSN (Print)1095-7863

Other

OtherNuclear Science Symposium Conference Record, 2005 IEEE
CountryPuerto Rico
Period05/10/2305/10/29

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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