Development of Elemental Technologies for Magnetic Hyperthermia in Cancer Treatment

Loi Tonthat, Fumitaka Aki, Kazutaka Mitobe, Shin Yabukami, Yoshiyuki Yamamoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Hyperthermia utilizing magnetic particles has been widely studied as a possible method for cancer treatment in recent years. This method induces apoptosis (cell death) using heat generation from magnetic particles which are injected into a tumor region and subjected to an external high-frequency magnetic field. In previous studies, we succeeded in developing microsize thermosensitive ferromagnetic particles with a low Curie temperature of around 40–45 °C as a self-controlled heating element that possibly prevents the local overheating surrounding healthy tissues. Further, by utilizing the change of its permeability around its Curie temperature resulting in the change in the magnetic flux density around tumor region, we also developed a wireless temperature measurement. In addition, to localize magnetic particles which cannot be seen from the body surface, we also developed an automatic localization system by using a robot arm equipped with three detection coils symmetrically installed in heating coil. To make our proposed elemental technologies feasible in clinical settings, we have also been developing a magnetic hyperthermia system that can treat deep-seated tumors up to 5 cm. In this paper, we report our elemental technologies which have been developed so far such as heating elements, temperature and position monitoring technologies.

Original languageEnglish
Title of host publication11th Asian-Pacific Conference on Medical and Biological Engineering - Proceedings of the Online Conference, APCMBE 2020
EditorsYasuyuki Shiraishi, Ichiro Sakuma, Keiji Naruse, Akinori Ueno
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages6
ISBN (Print)9783030661687
Publication statusPublished - 2021
Event11th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2020 - Okayama, Japan
Duration: 2020 May 252020 May 27

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277


Conference11th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2020


  • Hyperthermia
  • Magnetic particles
  • Position and temperature detection

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering


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