Development of drug carriers for therapy of arterioscleosis

Kenjiro Ikuta, Takeshi Mori, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama

Research output: Contribution to conferencePaperpeer-review

Abstract

The vascular endothelium dysfunction often leads to a cardiovascular disease such as arteriosclerosis. Therefore, detection and evaluation of vascular endothelium disorder in early stage would be very important for the effective diagnosis and therapy. We found that the structural analogues of Evans Blue adsorb to a vascular endothelium denuded region. Thus, we synthesized a polymeric drug carrier which consisted of amphipathic polymer and sensing unit (Evans Blue analogue) and evaluated the characteristics of the polymeric carriers. And then a extracted porcine aorta which was removed endothelial cell in left half area was treated with the micelle solution to evaluate a targeting ability of the micelle.

Original languageEnglish
Pages5459-5460
Number of pages2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Arteriosclerosis
  • Drug delivery systems
  • Endothelium dysfunction
  • Evans Blue analogue

ASJC Scopus subject areas

  • Engineering(all)

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