Development of diversity-enhanced extracts of curcuma zedoaria and their new sesquiterpene-like compounds

Haruhisa Kikuchi, Kazuyoshi Sakurai, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Through the combination of natural products chemistry and diversity-oriented synthesis, a new approach, diversity-enhanced extracts, for increasing the diversity of natural product-like compounds is proposed. They are prepared from chemical reactions that remodel molecular scaffolds directly on extracts of natural resources. This method was applied to terpenes extracted from Curcuma zedoaria. Epoxidation and subsequent ring-opening reactions of epoxides were used to modify molecular skeletons. As a result, seven sesquiterpene-like compounds with some containing new molecular skeletons were obtained.

Original languageEnglish
Pages (from-to)1916-1919
Number of pages4
JournalOrganic letters
Volume16
Issue number7
DOIs
Publication statusPublished - 2014 Apr 4

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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