Development of Behçet's disease in a Caucasian with human leukocyte antigen B51 after immigration to Japan

Takayuki Kimura; Yoshihide Asano; Mizuho Yamamoto; Makoto Sugaya; Shinichi Sato

doi:10.1111/j.1346-8138.2010.01125.x

Development of Behçet's disease in a Caucasian with human leukocyte antigen B51 after immigration to Japan

Takayuki Kimura, Yoshihide Asano, Mizuho Yamamoto, Makoto Sugaya, Shinichi Sato

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We herein report a 32-year-old Caucasian woman with human leukocyte antigen (HLA)-B51 who developed Behçet's disease after immigration to Japan. She was born and raised in Finland and had never experienced any clinical symptoms related to Behçet's disease before immigration to Japan. None of her family members in Finland had similar problems. Two years after the immigration, she developed typical clinical symptoms of Behçet's disease. This report strongly supports the canonical notion that the interaction of genetic factors, such as HLA-B51, with environmental factors specific to the countries in the Silk Road area, including Japan, may play a pivotal role in the pathogenesis of this disorder.

Original language	English
Pages (from-to)	581-584
Number of pages	4
Journal	Journal of Dermatology
Volume	38
Issue number	6
DOIs	https://doi.org/10.1111/j.1346-8138.2010.01125.x
Publication status	Published - 2011 Jun
Externally published	Yes

Keywords

Behçet's disease
Caucasian
environmental factors
human leukocyte antigen B51
Silk Road area

ASJC Scopus subject areas

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1346-8138.2010.01125.x

Cite this

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title = "Development of Beh{\c c}et's disease in a Caucasian with human leukocyte antigen B51 after immigration to Japan",

abstract = "We herein report a 32-year-old Caucasian woman with human leukocyte antigen (HLA)-B51 who developed Beh{\c c}et's disease after immigration to Japan. She was born and raised in Finland and had never experienced any clinical symptoms related to Beh{\c c}et's disease before immigration to Japan. None of her family members in Finland had similar problems. Two years after the immigration, she developed typical clinical symptoms of Beh{\c c}et's disease. This report strongly supports the canonical notion that the interaction of genetic factors, such as HLA-B51, with environmental factors specific to the countries in the Silk Road area, including Japan, may play a pivotal role in the pathogenesis of this disorder.",

keywords = "Beh{\c c}et's disease, Caucasian, environmental factors, human leukocyte antigen B51, Silk Road area",

author = "Takayuki Kimura and Yoshihide Asano and Mizuho Yamamoto and Makoto Sugaya and Shinichi Sato",

year = "2011",

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doi = "10.1111/j.1346-8138.2010.01125.x",

language = "English",

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journal = "Journal of Dermatology",

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T1 - Development of Behçet's disease in a Caucasian with human leukocyte antigen B51 after immigration to Japan

AU - Kimura, Takayuki

AU - Asano, Yoshihide

AU - Yamamoto, Mizuho

AU - Sugaya, Makoto

AU - Sato, Shinichi

PY - 2011/6

Y1 - 2011/6

N2 - We herein report a 32-year-old Caucasian woman with human leukocyte antigen (HLA)-B51 who developed Behçet's disease after immigration to Japan. She was born and raised in Finland and had never experienced any clinical symptoms related to Behçet's disease before immigration to Japan. None of her family members in Finland had similar problems. Two years after the immigration, she developed typical clinical symptoms of Behçet's disease. This report strongly supports the canonical notion that the interaction of genetic factors, such as HLA-B51, with environmental factors specific to the countries in the Silk Road area, including Japan, may play a pivotal role in the pathogenesis of this disorder.

AB - We herein report a 32-year-old Caucasian woman with human leukocyte antigen (HLA)-B51 who developed Behçet's disease after immigration to Japan. She was born and raised in Finland and had never experienced any clinical symptoms related to Behçet's disease before immigration to Japan. None of her family members in Finland had similar problems. Two years after the immigration, she developed typical clinical symptoms of Behçet's disease. This report strongly supports the canonical notion that the interaction of genetic factors, such as HLA-B51, with environmental factors specific to the countries in the Silk Road area, including Japan, may play a pivotal role in the pathogenesis of this disorder.

KW - Behçet's disease

KW - Caucasian

KW - environmental factors

KW - human leukocyte antigen B51

KW - Silk Road area

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Development of Behçet's disease in a Caucasian with human leukocyte antigen B51 after immigration to Japan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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