Development of an implantable small observation camera with scaffold chamber for angiogenesis

Y. Inoue, H. Nakagawa, I. Saito, T. Isoyama, H. Nakagawa, T. Ono, K. Ishii, E. Nakano, K. Imachi, Y. Abe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A miniaturized video camera system integrated with a scaffold for blood vessels and tissue induction that is implantable into an animal body was developed. A small autofocus camera with USB interface was used as an imaging device. A close-up lens was added to reduce the focusing point. Also 45-degree reflecting prism was added for the compact system design. A fabric poly-glycolic acid sheet of 0.3 mm thickness was used as a scaffold. The observation area was about 8 x 6 mm and the tissue was induced from sideways. The camera was implanted into a muscular layer of a goat for more than 9 weeks to observe the skeletal muscle induction. Tissue induction to the scaffold started from third week and it took about 9 weeks to cover the entire area by the tissue, Vigorous angiogenesis was observed at the front region of tissue induction resulting dense distribution of capillary vessels and red blood cells. The density of capillary vessels reduced considerably behind the front region and arterioles and venules started to appear.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Pages1961-1964
Number of pages4
DOIs
Publication statusPublished - 2013
EventWorld Congress on Medical Physics and Biomedical Engineering - Beijing, China
Duration: 2012 May 262012 May 31

Publication series

NameIFMBE Proceedings
Volume39 IFMBE
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering
CountryChina
CityBeijing
Period12/5/2612/5/31

Keywords

  • Angiogenesis
  • Implantable Camera
  • Microscope
  • Regenerative medicine
  • Scaffold
  • Tissue Engineering

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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