Development of an Implantable Observation System for Angiogenesis

Y. Inoue, H. Nakagawa, I. Saito, T. Isoyama, H. Miura, A. Kouno, T. Ono, S. S. Yamaguchi, W. Shi, A. Kishi, K. Imachi, Y. Abe

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    A miniaturized video camera system integrated with a scaffold for blood vessels and tissue induction that is implantable into an animal body was developed. A small auto-focus camera with USB interface was used as an imaging device. A close-up lens was added to reduce the focusing point. Also 45-degree reflecting prism was added for the compact system design. A spongy polyglycolic acid sheet of 0.3 mm thickness was used as a scaffold. The observation area was about 8 x 6 mm and the tissue was induced from sideways. The camera was implanted into a muscular layer of a goat for more than 60 days to observe the skeletal muscle induction. Tissue induction to the scaffold started from second week and it took about 5 weeks to cover the entire area by the tissue, Vigorous angiogenesis was observed at the front region of tissue induction resulting dense distribution of capillary vessels and red blood cells. The density of capillary vessels reduced considerably behind the front region and arterioles and venules started to appear.

    Original languageEnglish
    Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
    Pages1426-1429
    Number of pages4
    DOIs
    Publication statusPublished - 2009 Dec 1
    Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
    Duration: 2008 Dec 32008 Dec 6

    Publication series

    NameIFMBE Proceedings
    Volume23
    ISSN (Print)1680-0737

    Other

    Other13th International Conference on Biomedical Engineering, ICBME 2008
    CountrySingapore
    Period08/12/308/12/6

    Keywords

    • Angiogenesis
    • Implantable microscope
    • Tissue regeneration

    ASJC Scopus subject areas

    • Bioengineering
    • Biomedical Engineering

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