Development of an Implantable Observation System for Angiogenesis

Y. Inoue; H. Nakagawa; I. Saito; T. Isoyama; H. Miura; A. Kouno; T. Ono; S. S. Yamaguchi; W. Shi; A. Kishi; K. Imachi; Y. Abe

doi:10.1007/978-3-540-92841-6_352

Development of an Implantable Observation System for Angiogenesis

Y. Inoue, H. Nakagawa, I. Saito, T. Isoyama, H. Miura, A. Kouno, T. Ono, S. S. Yamaguchi, W. Shi, A. Kishi, K. Imachi, Y. Abe

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

A miniaturized video camera system integrated with a scaffold for blood vessels and tissue induction that is implantable into an animal body was developed. A small auto-focus camera with USB interface was used as an imaging device. A close-up lens was added to reduce the focusing point. Also 45-degree reflecting prism was added for the compact system design. A spongy polyglycolic acid sheet of 0.3 mm thickness was used as a scaffold. The observation area was about 8 x 6 mm and the tissue was induced from sideways. The camera was implanted into a muscular layer of a goat for more than 60 days to observe the skeletal muscle induction. Tissue induction to the scaffold started from second week and it took about 5 weeks to cover the entire area by the tissue, Vigorous angiogenesis was observed at the front region of tissue induction resulting dense distribution of capillary vessels and red blood cells. The density of capillary vessels reduced considerably behind the front region and arterioles and venules started to appear.

Original language	English
Title of host publication	13th International Conference on Biomedical Engineering - ICBME 2008
Pages	1426-1429
Number of pages	4
DOIs	https://doi.org/10.1007/978-3-540-92841-6_352
Publication status	Published - 2009 Dec 1
Event	13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore Duration: 2008 Dec 3 → 2008 Dec 6

Publication series

Name	IFMBE Proceedings
Volume	23
ISSN (Print)	1680-0737

Other

Other	13th International Conference on Biomedical Engineering, ICBME 2008
Country	Singapore
Period	08/12/3 → 08/12/6

Keywords

Angiogenesis
Implantable microscope
Tissue regeneration

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

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Cite this

Inoue, Y., Nakagawa, H., Saito, I., Isoyama, T., Miura, H., Kouno, A., Ono, T., Yamaguchi, S. S., Shi, W., Kishi, A., Imachi, K., & Abe, Y. (2009). Development of an Implantable Observation System for Angiogenesis. In 13th International Conference on Biomedical Engineering - ICBME 2008 (pp. 1426-1429). (IFMBE Proceedings; Vol. 23). https://doi.org/10.1007/978-3-540-92841-6_352

Development of an Implantable Observation System for Angiogenesis. / Inoue, Y.; Nakagawa, H.; Saito, I.; Isoyama, T.; Miura, H.; Kouno, A.; Ono, T.; Yamaguchi, S. S.; Shi, W.; Kishi, A.; Imachi, K.; Abe, Y.

13th International Conference on Biomedical Engineering - ICBME 2008. 2009. p. 1426-1429 (IFMBE Proceedings; Vol. 23).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Inoue, Y, Nakagawa, H, Saito, I, Isoyama, T, Miura, H, Kouno, A, Ono, T, Yamaguchi, SS, Shi, W, Kishi, A, Imachi, K & Abe, Y 2009, Development of an Implantable Observation System for Angiogenesis. in 13th International Conference on Biomedical Engineering - ICBME 2008. IFMBE Proceedings, vol. 23, pp. 1426-1429, 13th International Conference on Biomedical Engineering, ICBME 2008, Singapore, 08/12/3. https://doi.org/10.1007/978-3-540-92841-6_352

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