Development of an implantable artificial anal sphincter by the use of the shape memory alloy

Shintaro Amae, Motoshi Wada, Yun Luo, Hirokazu Nakamura, Shigehiko Yoshida, Takamichi Kamiyama, Tomoyuki Yambe, Toshiyuki Takagi, Shiniti Nitta, Ryoji Ohi

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

In this study, we developed and assessed an artificial anal sphincter driven by an shape memory alloy actuator (AS-SMA). The performance characteristics of the device were analyzed with a measurement system. Assessment showed that the AS-SMA could generate a pressure of 55 mm Hg at an atmospheric temperature of 36°C, and displacement of the SMA actuator was 7.5 mm when the temperature of the SMA plate was 55°C. To evaluate opening and closing, we studied a piglet colostomy model, in which the AS-SMA was implanted around the colostomy in the extraperitoneal space. Flow control tests using living porcine intestine revealed that the AS-SMA could maintain fecal continence against an intestinal pressure of 75 mm Hg. The high pressure zone corresponding to the location of the device was demonstrated in a manometric examination. For 6 days after surgery, we activated the AS-SMA twice a day and observed the bowel movements. The animal experiment indicated that the AS-SMA is able to control the bowel movements of patients with fecal incontinence if several problems, such as burning of tissue around the device and compression injury of the intestine, are resolved.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalASAIO Journal
Volume47
Issue number4
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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