Development of a method for cell delivery into the subretinal space using biodegradable nanosheets

Kazuya Yamashita, Hideto Kojima, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigated a minimally invasive and effective method for cell transplantation into the subretinal space. A biodegradable nanosheet as cell scaffold was fabricated from polycaprolactone (PCL) and collagen as low inflammatory materials and had sufficient strength and flexibility. Cell/nanosheet constructs were prepared by culturing cells on the nanosheets in a monolayer and injected into the subretinal space through the sclera of rat with a syringe needle. The cell/nanosheet construct was successively delivered into the subretinal space. This method holds great promise for transplantation of monolayer cells and for the development of local cell delivery systems.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1264-1265
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 2020 Oct 42020 Oct 9

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period20/10/420/10/9

Keywords

  • Cell delivery system
  • Cell scaffold
  • Cell transplantation
  • Polymeric membrane
  • Regenerative medicine

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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