Development of a flexible optical fiber based high resolution integrated PETMRI system

Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Tadashi Watabe, Masaaki Aoki, Eiji Sugiyama, Katsuhiko Kato, Jun Hatazawa

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Purpose: The simultaneous measurement of PET and magnetic resonance imaging (MRI) is an emerging field for molecular imaging research. Although optical fiber based PETMRI systems have advantages on less interference between PET and MRI, there is a drawback in reducing the scintillation light due to the fiber. To reduce the problem, the authors newly developed flexible optical fiber bundle based block detectors and employed them for a high resolution integrated PETMRI system. Methods: The flexible optical fiber bundle used 0.5 mm diameter, 80 cm long double clad fibers which have dual 12 mm × 24 mm rectangular inputs and a single 24 mm × 24 mm rectangular output. In the input surface, LGSO scintillators of 0.025 mol. (decay time: ∼31 ns: 0.9 mm × 1.3 mm × 5 mm) and 0.75 mol. (decay time: ∼46 ns: 0.9 mm × 1.3 mm × 6 mm) were optically coupled in depth direction to form depth-of-interaction detector, arranged in 11 × 13 matrix and optically coupled to the fiber bundle. The two inputs of the bundle are bent for 90°, bound to one, and are optically coupled to a Hamamatsu 1-in. square position sensitive photomultiplier tube. Results: Light loss due to the fiber bundle could be reduced and the performance of the block detectors was improved. Eight optical fiber based block detectors (16 LGSO blocks) were arranged in a 56 mm diameter ring to form a PET system. Spatial resolution and sensitivity were 1.2 mm full-width at half-maximum and 1.2 at the central field-of-view, respectively. Sensitivity change was less than 1 for 2 °C temperature changes. This PET system was integrated with a 0.3 T permanent magnet MRI system which has 17 cm diameter hole at the yoke area for insertion of the PET detector ring. There was no observable interference between PET and MRI. Simultaneous imaging of PET and MRI was successfully performed for small animal studies. Conclusions: The authors confirmed that the developed high resolution PETMRI system is promising for molecular imaging research.

Original languageEnglish
Pages (from-to)6660-6671
Number of pages12
JournalMedical Physics
Volume39
Issue number11
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • PET/MRI
  • high resolution
  • integrated
  • optical fiber

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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