Development of a database and ontology for pathogenic pathways in periodontitis

Asami Suzuki, Takako Takai-Igarashi, Yukihiro Numabe, Hiroshi Tanaka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

It is getting familiar that pathway information greatly contributes to elucidate the molecular basis of human disease with large-scale biological data. We developed a pathway database for molecular pathology in periodontitis named 'Pathogenic Pathway Database for Periodontitis'. Periodontitis is an inflammation disease in periodontal tissue and associated with an increased health risk of angina, myocardial infarction, and fetal cardiovascular events. Despite accumulation of biomedical research on periodontitis pathology at the molecular level, there has been no systematization for biological pathways in periodontitis. We checked 185 reference papers and extracted causal relationships among molecules as well as pathways representing molecular etiology. We also built an ontology that systematizes conceptual terms associated with the pathways. Besides pathways, our ontology provides cellular and tissue specific contextual information that is required to represent pathology at the cellular and tissue specific levels. We implemented in our database an integrated viewer for the association between pathways and ontology. Pathogenic Pathway Database for Periodontitis is freely available at http://bio-omix.tmd.ac.jp/disease/ perio/.

Original languageEnglish
Pages (from-to)233-243
Number of pages11
JournalIn silico biology
Volume9
Issue number4
DOIs
Publication statusPublished - 2009 Nov 17

Keywords

  • Alveolar bone resorption
  • Ontology
  • Pathogenic pathway
  • Pathway database
  • Periodontitis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Computational Mathematics
  • Computational Theory and Mathematics

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