Development of a chiral bis(guanidino)iminophosphorane as an uncharged organosuperbase for the enantioselective amination of ketones

Tadahiro Takeda, Masahiro Terada

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)

Abstract

Chiral bis(guanidino)iminophosphoranes were designed and synthesized as chiral uncharged organosuperbase catalysts that facilitate activation of less-acidic pro-nucleophiles. The newly developed bis(guanidino) iminophosphoranes, which possess the highest basicity among chiral organocatalysts reported to date, were proven to be a superb class of chiral organosuperbases by reaction of azodicarboxylates with 2-alkyltetralones and their analogues as the less acidic pro-nucleophiles.

Original languageEnglish
Pages (from-to)15306-15309
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number41
DOIs
Publication statusPublished - 2013 Oct 16

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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