Development and Validation of a Novel Prognostic Model for Predicting Overall Survival in Treatment-naïve Castration-sensitive Metastatic Prostate Cancer

Shusuke Akamatsu, Masashi Kubota, Ryuji Uozumi, Shintaro Narita, Masahiro Takahashi, Koji Mitsuzuka, Shingo Hatakeyama, Toshihiko Sakurai, Sadafumi Kawamura, Shigeto Ishidoya, Senji Hoshi, Masanori Ishida, Kei Mizuno, Keiji Ogura, Takayuki Goto, Naoki Terada, Takashi Kobayashi, Toshinari Yamasaki, Takahiro Inoue, Norihiko TsuchiyaChikara Ohyama, Yoichi Arai, Tomonori Habuchi, Satoshi Morita, Osamu Ogawa

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Background: There has been growth in the treatment options for castration-sensitive metastatic prostate cancer (mPCa), but without clear guidance for risk stratification. Objective: To identify clinical parameters associated with overall survival (OS) and establish a prognostic model for use with treatment-naïve castration-sensitive mPCa. Design, setting, and participants: A retrospective review of 304 patients treated at Kyoto University Hospital was performed. A prognostic model was created using clinical parameters associated with OS. The model was externally validated in an independent cohort of 520 patients. Outcome measurements and statistical analysis: Multivariable analysis was performed to identify the clinical parameters associated with OS. Risk scores were calculated using Cox proportional hazards analysis for each combination of risk factors, and patients were grouped into categories based on those scores. Results and limitations: Over 80% of the cohort had a Gleason sum score ≥8. The median OS was 53 mo among patients with CHAARTED high-volume PCa (n = 172) and 131 mo among those with low-volume PCa (n = 100). Independent factors associated with OS were extent of disease score ≥2 or the presence of liver metastasis; lactate dehydrogenase >250 U/L; and a primary Gleason score of 5. The median OS for the high-, intermediate-, and low-risk groups according to the new model were 28 mo, 59 mo, and not reached, respectively; the corresponding values in the validation cohort were 41 mo, 63 mo, and not reached. Harrell's C-index was 0.649. Conclusions: Our simple and reproducible prognostic model for treatment-naïve castration-sensitive mPCa could aid in risk stratification and treatment selection. Patient summary: We identified clinical parameters associated with prognosis in castration-sensitive metastatic prostate cancer and established a reproducible prognostic model that could be used to guide treatment decisions. We identified three readily available clinical parameters significantly associated with prognosis in castration-sensitive metastatic prostate cancer and established a highly reproducible prognostic model. The model could be used to guide treatment decisions or stratify patients in future clinical trials.

Original languageEnglish
Pages (from-to)320-328
Number of pages9
JournalEuropean Urology Oncology
Volume2
Issue number3
DOIs
Publication statusPublished - 2019 May
Externally publishedYes

Keywords

  • Hormone-naïve
  • Metastasis
  • Prognostic model
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine(all)

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