Development and performance evaluation of Time-over-Threshold based digital PET (TODPET2) scanner using SiPM/Ce:GAGG-arrays for non-invasive measurement of blood RI concentrations

Masao Yoshino, Kei Kamada, Y. Shoji, Akira Yoshikawa, K. Shimazoe, A. Lipovec, H. Takahashi, K. Fujiwara, M. Takahashi, T. Momose, S. Ito, K. Tsutsumi, T. Endo, Hiroki Sato, Y. Usuki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We developed Time-over-Threshold based digital PET (TODPET2) tomograph using silicon photomultipliers (SiPM) arrays coupled with pixelized Ce:Gd 3 (Ga, Al) 5 O 12 (Ce:GAGG) scintillators dedicated for non-invasive measurement of blood RI concentrations. The detector consists of 1.57 × 1.57 mm 2 SiPM chips and 1.6 × 1.6 × 15 mm 3 Ce:GAGG scintillators arranged on a 12 × 12 channel, both working as individual readout systems. After the development of the detector, we fabricated the PET gantry composed of 8 pieces of SiPM/Ce:GAGG detector array which signals were sent to the current-comparing type time-over-threshold (TOT) ASIC for individual readout of pixels. The PET scanner which we developed has 25 mm axial field-of-view (FOV) and 60 mm transaxial FOV. The spatial resolution reconstructed with maximum likelihood estimation method (MLEM) is 0.98 mm (FWHM) at the center of FOV. The sensitivity of the system is measured to be 1.31% using 22 Na point source. Finally, timing response to changes in RI concentration was also measured using 5 mm diameter syringe injected with several concentrations of 18FDG.

Original languageEnglish
Article numberC02028
JournalJournal of Instrumentation
Volume12
Issue number2
DOIs
Publication statusPublished - 2017 Feb 9

Keywords

  • Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA)
  • Gamma detectors (scintillators, CZT, HPG, HgI etc)

ASJC Scopus subject areas

  • Instrumentation
  • Mathematical Physics

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