TY - JOUR
T1 - [Development and neural basis of social behavior].
AU - Nakamura, Shun
AU - Karino, Genta
AU - Senoo, Aya
AU - Mimura, Koki
AU - Shirakawa, Yuka
AU - Yamazaki, Kazuyuki
AU - Fukushima, Yuta
AU - Obara, Saya
AU - Sekihara, Hitomi
AU - Ozawa, Shinpei
AU - Yui, Kunio
AU - Koshiba, Mamiko
PY - 2012
Y1 - 2012
N2 - We have developed a multi variate analysis of social communication behavior which allows for discriminating the emotional state of an agent interacting with other agents (Bouquet method). Domestic chick or common marmoset was reared under socially isolated conditions, later tested for its development of communication behavior with peers by Bouquet, and compared with that of animals reared under grouping conditions. We found the existence of high sensitive period for social interaction, given less experience, developing less affiliated behavior. From chick model, a couple of neuronal difference was observed between two groups, amygdale core central cell size, MRI volumetric measure in mesolimbic area, and gene expression patter including brain type tryptophan hydroxylase in nucleus accumbens. The isolated chick behavior changed better to be socially affiliated by taking SSRI/SNRI or Ubiquinol (the reduced form of CoQ10) together with social interaction experience after the sensitive period. Finally, we could discriminate the behavior of Asperger syndrome children (n = 7) from that of the typically developed siblings (n = 6) during the clinical interview by applying Bouquet method.
AB - We have developed a multi variate analysis of social communication behavior which allows for discriminating the emotional state of an agent interacting with other agents (Bouquet method). Domestic chick or common marmoset was reared under socially isolated conditions, later tested for its development of communication behavior with peers by Bouquet, and compared with that of animals reared under grouping conditions. We found the existence of high sensitive period for social interaction, given less experience, developing less affiliated behavior. From chick model, a couple of neuronal difference was observed between two groups, amygdale core central cell size, MRI volumetric measure in mesolimbic area, and gene expression patter including brain type tryptophan hydroxylase in nucleus accumbens. The isolated chick behavior changed better to be socially affiliated by taking SSRI/SNRI or Ubiquinol (the reduced form of CoQ10) together with social interaction experience after the sensitive period. Finally, we could discriminate the behavior of Asperger syndrome children (n = 7) from that of the typically developed siblings (n = 6) during the clinical interview by applying Bouquet method.
UR - http://www.scopus.com/inward/record.url?scp=84872040208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872040208&partnerID=8YFLogxK
M3 - Article
C2 - 23012854
AN - SCOPUS:84872040208
VL - 114
SP - 921
EP - 927
JO - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
JF - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
SN - 0033-2658
IS - 8
ER -