Development and application of compact and on-chip electron linear accelerators for dynamic tracking cancer therapy and DNA damage/repair analysis

M. Uesaka, K. Demachi, T. Fujiwara, K. Dobashi, H. Fujisawa, R. B. Chhatkuli, A. Tsuda, S. Tanaka, Y. Matsumura, S. Otsuki, J. Kusano, M. Yamamoto, N. Nakamura, E. Tanabe, K. Koyama, M. Yoshida, R. Fujimori, A. Yasui

    Research output: Contribution to journalConference articlepeer-review

    1 Citation (Scopus)

    Abstract

    We are developing compact electron linear accelerators (hereafter linac) with high RF (Radio Frequency) frequency (9.3 GHz, wavelength 32.3 mm) of X-band and applying to medicine and non-destructive testing. Especially, potable 950 keV and 3.95 MeV linac X-ray sources have been developed for on-site transmission testing at several industrial plants and civil infrastructures including bridges. 6 MeV linac have been made for pinpoint X-ray dynamic tracking cancer therapy. The length of the accelerating tube is ∼600 mm. The electron beam size at the X-ray target is less than 1 mm and X-ray spot size at the cancer is less than 3 mm. Several hardware and software are under construction for dynamic tracking therapy for moving lung cancer. Moreover, as an ultimate compact linac, we are designing and manufacturing a laser dielectric linac of ∼1 MeV with Yr fiber laser (283 THz, wavelength 1.06 pm). Since the wavelength is 1.06 μm, the length of one accelerating strcture is tens pm and the electron beam size is in sub-micro meter. Since the sizes of cell and nuclear are about 10 and 1 μm, respectively, we plan to use this "On-chip" linac for radiation-induced DNA damage/repair analysis. We are thinking a system where DNA in a nucleus of cell is hit by ∼1 μm electron or X-ray beam and observe its repair by proteins and enzymes in live cells in-situ.

    Original languageEnglish
    Article number012015
    JournalIOP Conference Series: Materials Science and Engineering
    Volume79
    Issue number1
    DOIs
    Publication statusPublished - 2015 Jun 10
    Event1st International Conference in Applied Physics and Materials Science, ICAMS 2013 - Davao City, Philippines
    Duration: 2013 Oct 242013 Oct 26

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)

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