Determination of phosphatidylcholine hydroperoxide (PCOOH) as a marker of membrane lipid peroxidation

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9 Citations (Scopus)

Abstract

Increasing evidence for phosphatidylcholine hydroperoxide (PCOOH) as a marker of oxidative food deterioration and oxidative diseases has revealed the need for a pure PCOOH standard and a reliable quantification method. Recently, we synthesized the PCOOH isomers 1-palmitoyl-2-(9-hydroperoxyoctadecadienoyl)-sn-glycero-3-phosphocholine, (16:0/9-HpODE PC) and 1-palmitoyl-2-(13-hydroperoxyoctadecadienoyl)-sn-glycero-3-phosphocholine (16:0/13-HpODE PC). Using these standards along with liquid chromatography-tandem mass spectrometry, a reliable quantification method was developed. This mini-review describes these analytical techniques, with a particular emphasis on clinical sample analysis.

Original languageEnglish
Pages (from-to)S78-S80
JournalJournal of nutritional science and vitaminology
Volume61
DOIs
Publication statusPublished - 2015 Nov 24

Keywords

  • Food deterioration
  • Lipid peroxidation
  • Mass spectrometry
  • Oxidative diseases
  • Phosphatidylcholine hydroperoxide

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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