Abstract
A new method for quantitation of captopril in human blood is described. Captopril was derivatized with N-(4-dimethylaminophenyl)maleimide into the electrochemically active adduct. The derivative was separated and determined by high-performance liquid chromatography with an electrochemical detector on a reversed-phase column. The proposed method was satisfactory for determination of captopril in whole blood with respect to accuracy and precision. The detection limit of captopril thereby obtained was 10 ng/ml. The blood levels of captopril in patients orally given an officinal dose were measured by the present method.
Original language | English |
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Pages (from-to) | 445-451 |
Number of pages | 7 |
Journal | Journal of Chromatography B: Biomedical Sciences and Applications |
Volume | 227 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1982 Feb 12 |
ASJC Scopus subject areas
- Chemistry(all)