Abstract
Two new reagents possessing ferrocene as an electrophore and isothiocyanate reactive toward the amino group were prepared and evaluated for pre-column derivatization of amino acids in highperformance liquid chromatography with electrochemical detection. The utilities of these reagents were investigated employing glycine as a model compound. Ferrocenylisothiocyanate was more favorable with respect to reactivity and electrochemical properties. The newly developed method was applied to the determination of 4-aminobutyric acid in biological specimens.
Original language | English |
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Pages (from-to) | 359-371 |
Number of pages | 13 |
Journal | Journal of Liquid Chromatography |
Volume | 12 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1989 Mar 1 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine