Detection of subgenotype IA and IIIA hepatitis A viruses in rivers flowing through metro Manila, the Philippines

Huimin Bai, Tomoyuki Shiota, Sayaka Yoshizaki, Mariko Saito-Obata, Fedelino F. Malbas, Socorro P. Lupisan, Hitoshi Oshitani, Naokazu Takeda, Masamichi Muramatsu, Takaji Wakita, Koji Ishii, Tian Cheng Li

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Hepatitis A virus (HAV) is a common infectious etiology of acute hepatitis worldwide. The Philippines remains highly endemic for hepatitis A, but there is still a lack of information about HAV in the country. To evaluate the HAV contamination in environmental water in the Philippines, we conducted the detection and genetic analyses of HAV RNA in samples from river water. Twelve water samples were collected at 6 sampling sites of 3 rivers in Metro Manila, in both the dry and wet seasons in 2012 and 2013. The HAV RNA was detected in all the 6 samples collected in the dry season, and in one sample from the wet season. Phylogenetic analysis confirmed that the HAV strains detected in the river water included multiple sequences belonging to subgenotypes IA and IIIA. This indicates that at least 2 genotypes of the HAV strains are circulating in the environment in the Philippines, posing a risk of HAV infection to not only residents, but also tourists, especially in the dry season.

Original languageEnglish
Pages (from-to)53-55
Number of pages3
JournalJapanese journal of infectious diseases
Issue number1
Publication statusPublished - 2019 Jan 31

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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