Detection of human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face

Masotoshi Deguchi, Yoshihisa Tomioka, Jyun Ya Okuguchi, Michinao Mizugaki, Hachiro Tagami

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We have detected human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face in a 78-year-old Japanese female farmer. Despite negative results with in situ hybridization performed with one generic biotin-labelled DNA probe that can detect HPV types 6, 11, 16, 18, 31, and 33, the polymerase chain reaction (PCR) with HPV type 18 primer detected the presence of HPV DNA. As far as we know, this is the first report of the detection of HPV type 18 DNA in the lesional skin of Bowen carcinoma in the general population. The prevalence of HPV infection in squamous cell carcinoma developing from Bowen's disease may be higher than we expected.

Original languageEnglish
Pages (from-to)487-488
Number of pages2
JournalEuropean Journal of Dermatology
Volume7
Issue number7
Publication statusPublished - 1997

Keywords

  • Human papillomavirus
  • In situ hybridization
  • Polymerase chain reaction
  • Skin cancer

ASJC Scopus subject areas

  • Dermatology

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