Detection of human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face

Masotoshi Deguchi; Yoshihisa Tomioka; Jyun Ya Okuguchi; Michinao Mizugaki; Hachiro Tagami

Detection of human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face

Masotoshi Deguchi, Yoshihisa Tomioka, Jyun Ya Okuguchi, Michinao Mizugaki, Hachiro Tagami

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We have detected human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face in a 78-year-old Japanese female farmer. Despite negative results with in situ hybridization performed with one generic biotin-labelled DNA probe that can detect HPV types 6, 11, 16, 18, 31, and 33, the polymerase chain reaction (PCR) with HPV type 18 primer detected the presence of HPV DNA. As far as we know, this is the first report of the detection of HPV type 18 DNA in the lesional skin of Bowen carcinoma in the general population. The prevalence of HPV infection in squamous cell carcinoma developing from Bowen's disease may be higher than we expected.

Original language	English
Pages (from-to)	487-488
Number of pages	2
Journal	European Journal of Dermatology
Volume	7
Issue number	7
Publication status	Published - 1997

Keywords

Human papillomavirus
In situ hybridization
Polymerase chain reaction
Skin cancer

ASJC Scopus subject areas

Dermatology

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title = "Detection of human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face",

abstract = "We have detected human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face in a 78-year-old Japanese female farmer. Despite negative results with in situ hybridization performed with one generic biotin-labelled DNA probe that can detect HPV types 6, 11, 16, 18, 31, and 33, the polymerase chain reaction (PCR) with HPV type 18 primer detected the presence of HPV DNA. As far as we know, this is the first report of the detection of HPV type 18 DNA in the lesional skin of Bowen carcinoma in the general population. The prevalence of HPV infection in squamous cell carcinoma developing from Bowen's disease may be higher than we expected.",

keywords = "Human papillomavirus, In situ hybridization, Polymerase chain reaction, Skin cancer",

author = "Masotoshi Deguchi and Yoshihisa Tomioka and Okuguchi, {Jyun Ya} and Michinao Mizugaki and Hachiro Tagami",

year = "1997",

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journal = "European Journal of Dermatology",

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T1 - Detection of human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face

AU - Deguchi, Masotoshi

AU - Tomioka, Yoshihisa

AU - Okuguchi, Jyun Ya

AU - Mizugaki, Michinao

AU - Tagami, Hachiro

PY - 1997

Y1 - 1997

N2 - We have detected human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face in a 78-year-old Japanese female farmer. Despite negative results with in situ hybridization performed with one generic biotin-labelled DNA probe that can detect HPV types 6, 11, 16, 18, 31, and 33, the polymerase chain reaction (PCR) with HPV type 18 primer detected the presence of HPV DNA. As far as we know, this is the first report of the detection of HPV type 18 DNA in the lesional skin of Bowen carcinoma in the general population. The prevalence of HPV infection in squamous cell carcinoma developing from Bowen's disease may be higher than we expected.

AB - We have detected human papillomavirus type 18 DNA in squamous cell carcinoma developing from Bowen's disease of the face in a 78-year-old Japanese female farmer. Despite negative results with in situ hybridization performed with one generic biotin-labelled DNA probe that can detect HPV types 6, 11, 16, 18, 31, and 33, the polymerase chain reaction (PCR) with HPV type 18 primer detected the presence of HPV DNA. As far as we know, this is the first report of the detection of HPV type 18 DNA in the lesional skin of Bowen carcinoma in the general population. The prevalence of HPV infection in squamous cell carcinoma developing from Bowen's disease may be higher than we expected.

KW - Human papillomavirus

KW - In situ hybridization

KW - Polymerase chain reaction

KW - Skin cancer

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