Detection of asymptomatic cardiac metastasis and successful salvage chemotherapy comprising a prednisone, etoposide, procarbazine, and cyclophosphamide regimen in an elderly japanese patient suffering from a delayed recurrence of diffuse large B-cell lymphoma

Keita Tagami, Shigeru Tanda, Hiroshi Kato, Atsushi Tashiro, Kenya Saji, Tatsuya Komaru, Muneo Tanida, Hiroshi Nakura, Kenichi Ishizawa

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    We report a case of facial diffuse large B-cell lymphoma (DLBCL) associated with recurrent metastasis in the heart and other sites in a 76-year-old Japanese woman. Initially, she developed DLBCL in her left upper eyelid that spread into the left orbit (Ann Arbor classification stage I). The lesion went into clinical regression after 4 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy followed by radiotherapy. More than 3 years later, the lymphoma recurred in her facial skin, together with metastases in the mediastinal lymph nodes and the heart; the tumor in the heart was successfully detected by PET/CT and cardiac MRI. To treat the recurrent lesions, we performed a salvage chemotherapy regimen comprising prednisone, etoposide, procarbazine, and cyclophosphamide, which successfully induced tumor regression.

    Original languageEnglish
    Pages (from-to)62-68
    Number of pages7
    JournalCase Reports in Oncology
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 2012 Jan

    Keywords

    • Cardiac MRI
    • Cardiacmetastasis
    • Diffuse large B-cell lymphoma
    • Malignant lymphoma
    • PET/CT
    • Prednisone, etoposide,procarbazine, and cyclophosphamide regimen
    • Recurrence
    • Salvage chemotherapy

    ASJC Scopus subject areas

    • Oncology

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