Abstract
The antibody to 65 KD mycobacterial heat shock protein (HSP65) and antibody to human superoxide dismutase (H-SOD) were measured by ELISA in patients with autoimmune hepatitis (AIH), and results were compared with those of patients with chronic active hepatitis C (CAH-C) or systemic lupus erythematosus (SLE) and normal subjects (NS). Patients with AIH had significantly higher OD values of anti-HSP65 antibody and anti-H-SOD antibody compared with those of patients with CAH-C or SLE and NS. OD values of anti-HSP65 antibody were correlated with those of anti-SOD antibody. Affinity-purified anti-SOD antibody reacted with HSP65. Analysis of the amino acid sequence of human SOD showed that 7 segments, corresponding to r to 25 amino acid residues, exhibited 50 to 71% homology with that of mycobacterial HSP65.
Original language | English |
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Pages (from-to) | 673-677 |
Number of pages | 5 |
Journal | Clinical Rheumatology |
Volume | 14 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1995 Nov |
Externally published | Yes |
Keywords
- Autoimmune Hepatitis
- Human 60 KD Heat Shock Protein
- Molecular Mimicry
- Mycobacterial 65 KD Heat Shock Protein
- Superoxide Dismutase
ASJC Scopus subject areas
- Rheumatology