Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase

M. Miyata, A. Kogure, H. Sato, E. Kodama, H. Watanabe, H. Ohira, M. Kuroda, T. Takagi, Y. Sato, R. Kasukawa

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The antibody to 65 KD mycobacterial heat shock protein (HSP65) and antibody to human superoxide dismutase (H-SOD) were measured by ELISA in patients with autoimmune hepatitis (AIH), and results were compared with those of patients with chronic active hepatitis C (CAH-C) or systemic lupus erythematosus (SLE) and normal subjects (NS). Patients with AIH had significantly higher OD values of anti-HSP65 antibody and anti-H-SOD antibody compared with those of patients with CAH-C or SLE and NS. OD values of anti-HSP65 antibody were correlated with those of anti-SOD antibody. Affinity-purified anti-SOD antibody reacted with HSP65. Analysis of the amino acid sequence of human SOD showed that 7 segments, corresponding to r to 25 amino acid residues, exhibited 50 to 71% homology with that of mycobacterial HSP65.

Original languageEnglish
Pages (from-to)673-677
Number of pages5
JournalClinical Rheumatology
Volume14
Issue number6
DOIs
Publication statusPublished - 1995 Nov

Keywords

  • Autoimmune Hepatitis
  • Human 60 KD Heat Shock Protein
  • Molecular Mimicry
  • Mycobacterial 65 KD Heat Shock Protein
  • Superoxide Dismutase

ASJC Scopus subject areas

  • Rheumatology

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