Detection of Alpaca Podoplanin by Immunohistochemistry Using the Antibovine Podoplanin Monoclonal Antibody PMab-44

Yukinari Kato, Shinji Yamada, Shunsuke Itai, Satoru Konnai, Atsushi Kobayashi, Mika K. Kaneko

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Podoplanin (PDPN) is expressed in type I alveolar cells of the lungs, lymphatic endothelial cells, and podocytes of the kidneys, and induces platelet aggregation through the C-type lectin-like receptor-2. PDPNs of various animal species have been characterized using specific anti-PDPN monoclonal antibodies (mAbs). However, alpaca PDPN has not previously been characterized because antialpaca PDPN mAbs have not yet been developed. In this study, we investigated the potential cross-reaction between established antibovine PDPN mAbs and alpaca PDPN. Using immunohistochemical analysis, type I alveolar cells of the alpaca lungs were detected by the antibovine PDPN mAb, PMab-44. These results indicate that PMab-44 may be useful for the detection of alpaca PDPN.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalMonoclonal antibodies in immunodiagnosis and immunotherapy
Volume37
Issue number6
DOIs
Publication statusPublished - 2018 Dec

Keywords

  • PMab-44
  • alpaca PDPN
  • alpaca podoplanin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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