Detailed deletion mapping on chromosome 1p32-p36 in human colorectal cancer: Identification of three distinct regions of common allelic loss

Michiko Matsuzaki, Satoru Nagase, Tadayoshi Abe, Ko Miura, Kenichi Shiiba, Makoto Sunamura, Akira Horii

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Recent studies have suggested the existence of one or several tumor- suppressor genes on chromosome arm 1p in colorectal tumors. To determine the localization of the putative tumor suppressor genes, we performed LOH analysis in 1p in colorectal tumors. A total of 48 paired normal and tumor DNAs of 46 colorectal tumor patients and 21 microsatellite markers on 1p32.1- p36.3 were used for Pcr-loh analysis. Three commonly deleted regions were found: i) 1p36.3 (10-cm); ii) 1p35.1-p36.3 (2-cm); and iii) 1p34.2-p35 (1- cm). These regions overlapped with those reported in several types of tumor. No significant associations were found between Loh and clinicopathologic features. The regions identified in the present study could harbor tumor suppressor genes that would also be associated with several types of human cancer.

Original languageEnglish
Pages (from-to)1229-1233
Number of pages5
JournalInternational journal of oncology
Volume13
Issue number6
DOIs
Publication statusPublished - 1998 Dec

Keywords

  • Allelic loss
  • Chromosome 1
  • Colorectal cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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