Destabilization of DNA through interstrand crosslinking by UO22+

André Rossberg, Takaya Abe, Koji Okuwaki, Astrid Barkleit, Kaori Fukuzawa, Tatsuya Nakano, Yuji Mochizuki, Satoru Tsushima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π-π stacking between the two nucleobases in the vicinity of UO22+-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO22+ binding.

Original languageEnglish
Pages (from-to)2015-2018
Number of pages4
JournalChemical Communications
Volume55
Issue number14
DOIs
Publication statusPublished - 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Rossberg, A., Abe, T., Okuwaki, K., Barkleit, A., Fukuzawa, K., Nakano, T., Mochizuki, Y., & Tsushima, S. (2019). Destabilization of DNA through interstrand crosslinking by UO22+. Chemical Communications, 55(14), 2015-2018. https://doi.org/10.1039/c8cc09329f