Design, preparation and assessment of surface-immobilised tetraphenylethenes for biosensing applications

Johannes Brennecke, Christopher J. Ochs, Aïcha Boudhar, Bastien Reux, Gomathy Sandhya Subramanian, Martin J. Lear, Dieter Trau, Jonathan Hobley

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Tetraphenylethene (TPE) shows a significant increase of fluorescence intensity when the rotational freedom of its phenyl groups is restricted. This special property allows the use of TPE in sensor applications, which have been previously described for the liquid phase only. However, some applications utilising arrays require the immobilisation of TPE dyes on solid surfaces. In this work, we synthesised and investigated the fluorescence behaviour of TPE derivatives on silica particles and quartz slides and suggest ways to employ the dye's properties in solid phase biosensor applications.

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalApplied Surface Science
Volume307
DOIs
Publication statusPublished - 2014 Jul 15

Keywords

  • Bioassay
  • Fluorescent dye
  • Microparticles
  • Reagentless assay
  • Tetraphenylethene

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Physics and Astronomy(all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films

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