Design of well-defined hydrogels by nanogel engineering

Nobuyuki Morimoto, Takafumi Ohki, Kimio Kurita, Yasuhiko Iwasaki, Kazunari Akiyoshi

Research output: Contribution to conferencePaperpeer-review

Abstract

We develop tailor-made functional nanogels to create novel nanobiomaterials (nanogel engineering) by self-assembling of functional associating polymers as building blocks. Self-assembled nanogels containing polymerizable groups (nanogelomers) were designed as key building blocks. Hybrid hydrogels were prepared by copolymerization of the nanogelomers in the presence or absence of 2-methacryloyloxyethyl phosphorylcholine (MPC) in semi-dilute aqueous condition. CHPMA nanogelomers acted as a cross-linker and CHP-MPC hybrid hydrogels were prepared. The hydrogels spontaneously trapped proteins. By adding ß-CD solution, trapped proteins were released as native form. The hydrogels are now applied to the artificial molecular chaperone system. We can control the formation of well-defined nano-structured hydrogels by polymerization of methacryloyl group-bearing nanogels in their appropriate condition.

Original languageEnglish
Pages4731-4732
Number of pages2
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • 2-methacryloyloxyethyl phosphorylcholine
  • Cholesteryl group bearing pullulan
  • Hydrogel
  • Nanogel
  • Self-assembly

ASJC Scopus subject areas

  • Engineering(all)

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