Design of S-S bond containing maleimide-conjugated: Closo -dodecaborate (SSMID): Identification of unique modification sites on albumin and investigation of intracellular uptake

Satomu Ishii, Shinichi Sato, Hiroya Asami, Tomoko Hasegawa, Jun Ya Kohno, Hiroyuki Nakamura

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

An S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID) was synthesised for identification of albumin binding sites. Three Lys residues, Lys221, Lys413 and Lys431, were identified as SSMID modification sites in addition to Cys34 in bovin serum albumin (BSA). Fluorescent-labelled MID-BSA was found to be accumulated in the cytosol of HeLa cells.

Original languageEnglish
Pages (from-to)5496-5499
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number22
DOIs
Publication statusPublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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