Design of resolving reagents: p-substituted mandelic acids as resolving reagents for 1-arylalkylamines

Kazushi Kinbara; Kenichi Sakai; Yukihiko Hashimoto; Hiroyuki Nohira; Kazuhiko Saigo

doi:10.1016/0957-4166(96)00175-9

Design of resolving reagents: p-substituted mandelic acids as resolving reagents for 1-arylalkylamines

Kazushi Kinbara, Kenichi Sakai, Yukihiko Hashimoto, Hiroyuki Nohira, Kazuhiko Saigo

Institute of Multidisciplinary Research for Advanced Materials (IMRAM)

Research output: Contribution to journal › Article

59 Citations (Scopus)

Abstract

The resolution of 1-arylalkylamines 2-10 by mandelic acid 1 was studied. It was found that a substituent, which elongated the molecular length of the amines, diminished the resolution efficiency. On the basis of these results, (S)-p-methylmandelic acid (S)-11 and (R)-p-methoxymandelic acid (R)-12 were selected as new resolving reagents for the 1-arylalkylamines; these acids were found to have a higher resolving ability than (R)-1.

Original language	English
Pages (from-to)	1539-1542
Number of pages	4
Journal	Tetrahedron Asymmetry
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/0957-4166(96)00175-9
Publication status	Published - 1996 Jun

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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abstract = "The resolution of 1-arylalkylamines 2-10 by mandelic acid 1 was studied. It was found that a substituent, which elongated the molecular length of the amines, diminished the resolution efficiency. On the basis of these results, (S)-p-methylmandelic acid (S)-11 and (R)-p-methoxymandelic acid (R)-12 were selected as new resolving reagents for the 1-arylalkylamines; these acids were found to have a higher resolving ability than (R)-1.",

author = "Kazushi Kinbara and Kenichi Sakai and Yukihiko Hashimoto and Hiroyuki Nohira and Kazuhiko Saigo",

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AU - Nohira, Hiroyuki

AU - Saigo, Kazuhiko

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