Design of resolving reagents: p-substituted mandelic acids as resolving reagents for 1-arylalkylamines

Kazushi Kinbara, Kenichi Sakai, Yukihiko Hashimoto, Hiroyuki Nohira, Kazuhiko Saigo

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The resolution of 1-arylalkylamines 2-10 by mandelic acid 1 was studied. It was found that a substituent, which elongated the molecular length of the amines, diminished the resolution efficiency. On the basis of these results, (S)-p-methylmandelic acid (S)-11 and (R)-p-methoxymandelic acid (R)-12 were selected as new resolving reagents for the 1-arylalkylamines; these acids were found to have a higher resolving ability than (R)-1.

Original languageEnglish
Pages (from-to)1539-1542
Number of pages4
JournalTetrahedron Asymmetry
Volume7
Issue number6
DOIs
Publication statusPublished - 1996 Jun

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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