Design of resolving agents based on crystal engineering

Kazushi Kinbara

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

As a result of systematic studies on the optical resolution of racemates via crystallization, we have found that in many cases, common characteristic hydrogen-bond networks were formed in the less-soluble diastereomeric salts or conglomerates. Design of resolving/derivatizing agents could be achieved on the basis of the concept of crystal engineering, by which molecules were designed to achieve stable hydrogen-bond networks with target racemates.

Original languageEnglish
Pages (from-to)732-743
Number of pages12
JournalSynlett
Issue number5
DOIs
Publication statusPublished - 2005 Mar 21

Keywords

  • Chiral resolution
  • Chirality
  • Enantiomeric resolution
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Organic Chemistry

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