Design of nanogel crosslinked hydrogels and function as artificial molecular chaperone

Nobuyuki Morimoto, Kazunari Akiyoshi

Research output: Contribution to conferencePaper

Abstract

We develop tailor-made functional nanogels to create novel nanobiomaterials (nanogel engineering) by self-assembling of functional associating polymers as building blocks. Self-assembled nanogels containing polymerizable groups (CHPMA) were designed as key building blocks. Hybrid hydrogels were prepared by copolymerization of the CHPMA with 2-methacryloyloxyethyl phosphorylcholine (MPC) in semi-dilute aqueous condition. The hydrogels trapped proteins in denatured form and rapidly released by adding ß-CD solution. The released proteins were refolded as native form. The hydrogels worked well as an artificial molecular chaperone system for protein refolding.

Original languageEnglish
Pages4522-4523
Number of pages2
Publication statusPublished - 2006 Dec 1
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • 2-Methacryloyloxyethyl phosphorylcholine
  • Artificial molecular chaperone
  • Cholesteryl group bearing pullulan
  • Hydrogel
  • Nanogel

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Design of nanogel crosslinked hydrogels and function as artificial molecular chaperone'. Together they form a unique fingerprint.

  • Cite this

    Morimoto, N., & Akiyoshi, K. (2006). Design of nanogel crosslinked hydrogels and function as artificial molecular chaperone. 4522-4523. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.