Abstract
We develop tailor-made functional nanogels to create novel nanobiomaterials (nanogel engineering) by self-assembling of functional associating polymers as building blocks. Self-assembled nanogels containing polymerizable groups (CHPMA) were designed as key building blocks. Hybrid hydrogels were prepared by copolymerization of the CHPMA with 2-methacryloyloxyethyl phosphorylcholine (MPC) in semi-dilute aqueous condition. The hydrogels trapped proteins in denatured form and rapidly released by adding ß-CD solution. The released proteins were refolded as native form. The hydrogels worked well as an artificial molecular chaperone system for protein refolding.
| Original language | English |
|---|---|
| Pages | 4522-4523 |
| Number of pages | 2 |
| Publication status | Published - 2006 Dec 1 |
| Externally published | Yes |
| Event | 55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: 2006 Sep 20 → 2006 Sep 22 |
Other
| Other | 55th Society of Polymer Science Japan Symposium on Macromolecules |
|---|---|
| Country | Japan |
| City | Toyama |
| Period | 06/9/20 → 06/9/22 |
Keywords
- 2-Methacryloyloxyethyl phosphorylcholine
- Artificial molecular chaperone
- Cholesteryl group bearing pullulan
- Hydrogel
- Nanogel
ASJC Scopus subject areas
- Engineering(all)
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Cite this
Morimoto, N., & Akiyoshi, K. (2006). Design of nanogel crosslinked hydrogels and function as artificial molecular chaperone. 4522-4523. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.