Design of highly efficient and selective transfer reaction of nitrosyl group to dC and dMC resulting in specific deamination

Md Monsur Ali, Fumi Nagatsugi, Shizuka Nakayama, Md Rowshon Alam, Takeshi Kawasaki, Shigeki Sasaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nitric oxide (NO) is an important endogenous regulatory molecule, and S-nitrosothiols are believed to play a significant role in NO storage, transport, and delivery. Based on the ability to generate NO in vivo, S-nitrosothiols can be used as therapeutic drugs. In this study, we have developed an innovative method for sequence- and base-specific delivery of NO to a specific site of DNA followed by specific deamination.

Original languageEnglish
Pages (from-to)721-724
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume24
Issue number5-7
DOIs
Publication statusPublished - 2005 Oct 20
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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