Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery

Kiyotaka Maruoka; Yoshitaka Koseki; Anh Thi Ngoc Dao; Ryuju Suzuki; Anudari Batbayar; Nagaki Sugeno; Hirohito Umezawa; Hitoshi Kasai

doi:10.1080/15421406.2022.2056384

Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery

Kiyotaka Maruoka, Yoshitaka Koseki, Anh Thi Ngoc Dao, Ryuju Suzuki, Anudari Batbayar, Nagaki Sugeno, Hirohito Umezawa, Hitoshi Kasai

Materials-Measurement Hybrid Research Center

Research output: Contribution to journal › Article › peer-review

Abstract

In nanoparticle-based drug delivery systems, dispersion stability is one of the most significant factors controlling drug efficacy and side effects. Herein, we synthesized guaiazulene derivatives-conjugated podophyllotoxin prodrugs and fabricated their nanoparticles (GA-C_N-PPT nano-prodrugs). GA-C_N-PPT nano-prodrugs were obtained with a size of about 100 nm and possessed high dispersion stability. The cytotoxicity was tunable by changing the length of the carbon chain linker. Notably, the release rate of PPT was the key factor for the anticancer activity of GA-C_N-PPT nano-prodrugs. The nano-prodrugs could serve as a promising template for developing a novel delivery system using nano-prodrugs.

Original language	English
Pages (from-to)	100-108
Number of pages	9
Journal	Molecular crystals and liquid crystals
Volume	744
Issue number	1
DOIs	https://doi.org/10.1080/15421406.2022.2056384
Publication status	Published - 2022

Keywords

Nano-prodrugs
guaiazulene
podophyllotoxin
reprecipitation method

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Condensed Matter Physics

Access to Document

10.1080/15421406.2022.2056384

Cite this

@article{2418a57e85814a458c67c361cd024e92,

title = "Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery",

abstract = "In nanoparticle-based drug delivery systems, dispersion stability is one of the most significant factors controlling drug efficacy and side effects. Herein, we synthesized guaiazulene derivatives-conjugated podophyllotoxin prodrugs and fabricated their nanoparticles (GA-CN-PPT nano-prodrugs). GA-CN-PPT nano-prodrugs were obtained with a size of about 100 nm and possessed high dispersion stability. The cytotoxicity was tunable by changing the length of the carbon chain linker. Notably, the release rate of PPT was the key factor for the anticancer activity of GA-CN-PPT nano-prodrugs. The nano-prodrugs could serve as a promising template for developing a novel delivery system using nano-prodrugs.",

keywords = "Nano-prodrugs, guaiazulene, podophyllotoxin, reprecipitation method",

author = "Kiyotaka Maruoka and Yoshitaka Koseki and Dao, {Anh Thi Ngoc} and Ryuju Suzuki and Anudari Batbayar and Nagaki Sugeno and Hirohito Umezawa and Hitoshi Kasai",

note = "Funding Information: This study was supported by JSPS Grants-in-Aid for Scientific Research (No. 19K15690, and No. 19H02785), the Cooperative Research Program of “Network Joint Research Center for Materials and Devices”, and the Research Program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials” in “Network Joint Research Center for Materials and Devices”. Publisher Copyright: {\textcopyright} 2022 Taylor & Francis Group, LLC.",

year = "2022",

doi = "10.1080/15421406.2022.2056384",

language = "English",

volume = "744",

pages = "100--108",

journal = "Molecular Crystals and Liquid Crystals",

issn = "1542-1406",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery

AU - Maruoka, Kiyotaka

AU - Koseki, Yoshitaka

AU - Dao, Anh Thi Ngoc

AU - Suzuki, Ryuju

AU - Batbayar, Anudari

AU - Sugeno, Nagaki

AU - Umezawa, Hirohito

AU - Kasai, Hitoshi

N1 - Funding Information: This study was supported by JSPS Grants-in-Aid for Scientific Research (No. 19K15690, and No. 19H02785), the Cooperative Research Program of “Network Joint Research Center for Materials and Devices”, and the Research Program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials” in “Network Joint Research Center for Materials and Devices”. Publisher Copyright: © 2022 Taylor & Francis Group, LLC.

PY - 2022

Y1 - 2022

N2 - In nanoparticle-based drug delivery systems, dispersion stability is one of the most significant factors controlling drug efficacy and side effects. Herein, we synthesized guaiazulene derivatives-conjugated podophyllotoxin prodrugs and fabricated their nanoparticles (GA-CN-PPT nano-prodrugs). GA-CN-PPT nano-prodrugs were obtained with a size of about 100 nm and possessed high dispersion stability. The cytotoxicity was tunable by changing the length of the carbon chain linker. Notably, the release rate of PPT was the key factor for the anticancer activity of GA-CN-PPT nano-prodrugs. The nano-prodrugs could serve as a promising template for developing a novel delivery system using nano-prodrugs.

AB - In nanoparticle-based drug delivery systems, dispersion stability is one of the most significant factors controlling drug efficacy and side effects. Herein, we synthesized guaiazulene derivatives-conjugated podophyllotoxin prodrugs and fabricated their nanoparticles (GA-CN-PPT nano-prodrugs). GA-CN-PPT nano-prodrugs were obtained with a size of about 100 nm and possessed high dispersion stability. The cytotoxicity was tunable by changing the length of the carbon chain linker. Notably, the release rate of PPT was the key factor for the anticancer activity of GA-CN-PPT nano-prodrugs. The nano-prodrugs could serve as a promising template for developing a novel delivery system using nano-prodrugs.

KW - Nano-prodrugs

KW - guaiazulene

KW - podophyllotoxin

KW - reprecipitation method

UR - http://www.scopus.com/inward/record.url?scp=85127265534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85127265534&partnerID=8YFLogxK

U2 - 10.1080/15421406.2022.2056384

DO - 10.1080/15421406.2022.2056384

M3 - Article

AN - SCOPUS:85127265534

SN - 1542-1406

VL - 744

SP - 100

EP - 108

JO - Molecular Crystals and Liquid Crystals

JF - Molecular Crystals and Liquid Crystals

IS - 1

ER -

Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this