Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair

Shigeki Sasaki, Shouji Nakashima, Fumi Nagatsugi, Yoshitsugu Tanaka, Masao Hisatome, Minoru Maeda

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A new artificial nucleobase (1) was designed for the selective formation of a triple-complex with a cytosine-guanine base pair at the major groove site. It has been proved based on the 1D- and 2D 1H-NMR spectra that the protected 2′-oxy-1 (7) forms a triplex complex with the GC pair selectively.

Original languageEnglish
Pages (from-to)9521-9524
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number52
DOIs
Publication statusPublished - 1995 Dec 25
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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