Design of a double functional interface polymer with artificial biomembrane for control of anti-and pro-tissue adhesion

Mizuna Kimura; Tomohiro Konno; Toru Moro; Madoka Takai; Kazuhiko Ishihara

Design of a double functional interface polymer with artificial biomembrane for control of anti-and pro-tissue adhesion

Mizuna Kimura, Tomohiro Konno, Toru Moro, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to conference › Paper › peer-review

Abstract

The aim of this study is to create a novel bioadhesive with double functional interfaces; one is pro-tissue adhesive to the applied tissue and the other is anti-adhesive between the material and the normal tissue. We are reporting a polymeric system using the activated-estered poly(lactic acid) particle and poly(MPC-co-acrylamide). The particle enables biodegradation and tissue adhesion via chemical cross-linking. The amino groups in the PMAam can also form amide bondings with the activated ester on the particle surface and result in spontaneous gelation. The MPC unit in PMAam is expected to provide biocompatibility and suppress adhesion between the material and the normal tissue.

Original language	English
Pages	5231-5232
Number of pages	2
Publication status	Published - 2005 Dec 1
Externally published	Yes
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 2005 Sep 20 → 2005 Sep 22

Other

Other	54th SPSJ Symposium on Macromolecules
Country	Japan
City	Yamagata
Period	05/9/20 → 05/9/22

Keywords

Antiadhesion
Microparticle
MPC
Tissue adhesion

ASJC Scopus subject areas

Engineering(all)

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title = "Design of a double functional interface polymer with artificial biomembrane for control of anti-and pro-tissue adhesion",

abstract = "The aim of this study is to create a novel bioadhesive with double functional interfaces; one is pro-tissue adhesive to the applied tissue and the other is anti-adhesive between the material and the normal tissue. We are reporting a polymeric system using the activated-estered poly(lactic acid) particle and poly(MPC-co-acrylamide). The particle enables biodegradation and tissue adhesion via chemical cross-linking. The amino groups in the PMAam can also form amide bondings with the activated ester on the particle surface and result in spontaneous gelation. The MPC unit in PMAam is expected to provide biocompatibility and suppress adhesion between the material and the normal tissue.",

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T1 - Design of a double functional interface polymer with artificial biomembrane for control of anti-and pro-tissue adhesion

AU - Kimura, Mizuna

AU - Konno, Tomohiro

AU - Moro, Toru

AU - Takai, Madoka

AU - Ishihara, Kazuhiko

PY - 2005/12/1

Y1 - 2005/12/1

N2 - The aim of this study is to create a novel bioadhesive with double functional interfaces; one is pro-tissue adhesive to the applied tissue and the other is anti-adhesive between the material and the normal tissue. We are reporting a polymeric system using the activated-estered poly(lactic acid) particle and poly(MPC-co-acrylamide). The particle enables biodegradation and tissue adhesion via chemical cross-linking. The amino groups in the PMAam can also form amide bondings with the activated ester on the particle surface and result in spontaneous gelation. The MPC unit in PMAam is expected to provide biocompatibility and suppress adhesion between the material and the normal tissue.

AB - The aim of this study is to create a novel bioadhesive with double functional interfaces; one is pro-tissue adhesive to the applied tissue and the other is anti-adhesive between the material and the normal tissue. We are reporting a polymeric system using the activated-estered poly(lactic acid) particle and poly(MPC-co-acrylamide). The particle enables biodegradation and tissue adhesion via chemical cross-linking. The amino groups in the PMAam can also form amide bondings with the activated ester on the particle surface and result in spontaneous gelation. The MPC unit in PMAam is expected to provide biocompatibility and suppress adhesion between the material and the normal tissue.

KW - Antiadhesion

KW - Microparticle

KW - MPC

KW - Tissue adhesion

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