Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate

Naoki Kanoh, Kosuke Mano, Daisuke Saigusa, Takeo Usui, Yoshiharu Iwabuchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Extracellular administration of water-soluble and membrane-permeant analogs of phosphatidylinositol phosphates (PIPs) is a useful strategy for understanding the cellular roles of PIPs as well as the mode of action of drugs whose biological activity is associated with PIPs. We herein established the synthetic route to the dioctanoyl analogue of phosphatidylinositol 3,5-bisphosphate (di-C8-PI(3,5)P2) and its penta(acetoxymethyl) ester (di-C8-PI(3,5)P2/5AM).

Original languageEnglish
Pages (from-to)5770-5772
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number23
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Acetoxymethyl ester
  • Chemical synthesis
  • Dioctanoyl analog
  • Phosphatidylinositol 3,5-bisphosphates

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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