Design and synthesis of the novel cross-linking reagents triggered by the triple helix formation.

F. Nagatsugi, D. Usui, T. Kawasaki, M. Maeda, S. Sasaki

Research output: Contribution to journalArticlepeer-review

Abstract

In our attempt to new nucleobase analogs capable of interstrand cross-linking, we developed 2-amino-6-vinyl purine analog (1). The oligonucleotides incorporating 1 showed efficient interstrand cross-linking with selectivity toward cytidine at a target site. In this paper, we describe the design of the new cross-linking reagents (2) bearing 2-amino-6-vinyl purine motif, and triplex-directed alkylation with 2 to double-stranded DNA.

Original languageEnglish
Pages (from-to)39-40
Number of pages2
JournalNucleic acids symposium series
Issue number44
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Medicine(all)

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