Design and synthesis of the novel cross-linking agent.

Shuhei Kusano, Keiichi Hattori, Shuhei Imoto, Fumi Nagatsugi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Previously, we have developed a highly efficient and selective cross-linking reaction to the cytosine base at the target site of DNA using the oligodeoxynucleotide (ODN) containing 2-amino-6-vinylpurine derivative (1). Based on these results, we have designed the novel cross-linking agents, which are pyrimidine derivatives having two hydrogen bond sites and vinyl group as a reactive moiety. In this paper, we wish to report the results to investigate on the synthesis of the pyrimidine derivatives having potential as novel cross-linking agents.

Original languageEnglish
Pages (from-to)169-170
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number53
Publication statusPublished - 2009 Jan 1

ASJC Scopus subject areas

  • Medicine(all)

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