Design and synthesis of telomestatin derivatives and their inhibitory activity of telomerase

Masayuki Tera, Yoshihiro Sohtome, Hiromichi Ishizuka, Takayuki Doi, Motoki Takagi, Kazuo Shin-ya, Kazuo Nagasawa

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Telomestatin derivatives of 2a-2c, which have macrocyclic bisamide structure, were designed and synthesized. One of these compounds (2a) showed inhibitory activity of telomerase with an 1C50 of 2μM.

Original languageEnglish
Pages (from-to)505-514
Number of pages10
JournalHeterocycles
Volume69
Issue number1
DOIs
Publication statusPublished - 2006 Dec 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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