Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus

Shinya Oishi, Yasuyo Kodera, Hiroki Nishikawa, Hirotaka Kamitani, Tsuyoshi Watabe, Hiroaki Ohno, Tadafumi Tochikura, Kazuki Shimane, Eiichi Kodama, Masao Matsuoka, Fuminori Mizukoshi, Hajime Tsujimoto, Nobutaka Fujii

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Feline immunodeficiency virus (FIV) is a pathogenic virus that causes an AIDS-like syndrome in the domestic cats. For viral entry and infection, fusion between the virus and the cell membrane is the critical process and this process is mediated by an envelope glycoprotein gp40. We have identified fusion inhibitory peptides from the heptad repeat-2 (HR2) of gp40. Remodeling of the original sequences using α-helix-inducible motifs revealed the interactive residues of gp40. Comparative analysis of HR2 peptides derived from four FIV strains demonstrated that the interactive surface of the Shizuoka strain-derived HR2 peptides provides the highest affinity of all the FIV strains examined.

Original languageEnglish
Pages (from-to)4916-4920
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number14
DOIs
Publication statusPublished - 2009 Jul 15
Externally publishedYes

Keywords

  • Feline immunodeficiency virus
  • Fusion inhibitor
  • Heptad repeat
  • α-Helix

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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