Design and synthesis of fluorine-18 labeled matrix metalloproteinase inhibitors for cancer imaging

Shozo Furumoto; Ren Iwata; Tatsuo Ido

doi:10.1002/jlcr.616

Design and synthesis of fluorine-18 labeled matrix metalloproteinase inhibitors for cancer imaging

Shozo Furumoto, Ren Iwata, Tatsuo Ido

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) are key enzymes involved in cancer invasion and metastasis. New ¹⁸F-labeled MMP inhibitors (1a-c) has been designed and synthesized for cancer imaging by positron emmision tomography. The precursors were synthesized in four steps starting from D-form of amino acids. Radiosynthesis of 1a-c were carried out by simple one-pot synthesis. The resulting radiofluorinated MMP inhibitors were obtained in overall radiochemical yields of 13-43% (EOB, decay corrected) within 60-70 min (including final preparative HPLC separation).

Original language	English
Pages (from-to)	975-986
Number of pages	12
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	45
Issue number	11
DOIs	https://doi.org/10.1002/jlcr.616
Publication status	Published - 2002 Oct 15

Keywords

Fluorine-18
Inhibitor
Matrix metalloproteinase
Pet
Tumor imaging

ASJC Scopus subject areas

Analytical Chemistry
Drug Discovery
Organic Chemistry
Clinical Biochemistry
Molecular Medicine
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jlcr.616

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abstract = "Matrix metalloproteinases (MMPs) are key enzymes involved in cancer invasion and metastasis. New 18F-labeled MMP inhibitors (1a-c) has been designed and synthesized for cancer imaging by positron emmision tomography. The precursors were synthesized in four steps starting from D-form of amino acids. Radiosynthesis of 1a-c were carried out by simple one-pot synthesis. The resulting radiofluorinated MMP inhibitors were obtained in overall radiochemical yields of 13-43% (EOB, decay corrected) within 60-70 min (including final preparative HPLC separation).",

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T1 - Design and synthesis of fluorine-18 labeled matrix metalloproteinase inhibitors for cancer imaging

AU - Furumoto, Shozo

AU - Iwata, Ren

AU - Ido, Tatsuo

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Y1 - 2002/10/15

N2 - Matrix metalloproteinases (MMPs) are key enzymes involved in cancer invasion and metastasis. New 18F-labeled MMP inhibitors (1a-c) has been designed and synthesized for cancer imaging by positron emmision tomography. The precursors were synthesized in four steps starting from D-form of amino acids. Radiosynthesis of 1a-c were carried out by simple one-pot synthesis. The resulting radiofluorinated MMP inhibitors were obtained in overall radiochemical yields of 13-43% (EOB, decay corrected) within 60-70 min (including final preparative HPLC separation).

AB - Matrix metalloproteinases (MMPs) are key enzymes involved in cancer invasion and metastasis. New 18F-labeled MMP inhibitors (1a-c) has been designed and synthesized for cancer imaging by positron emmision tomography. The precursors were synthesized in four steps starting from D-form of amino acids. Radiosynthesis of 1a-c were carried out by simple one-pot synthesis. The resulting radiofluorinated MMP inhibitors were obtained in overall radiochemical yields of 13-43% (EOB, decay corrected) within 60-70 min (including final preparative HPLC separation).

KW - Fluorine-18

KW - Inhibitor

KW - Matrix metalloproteinase

KW - Pet

KW - Tumor imaging

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JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

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ER -

Design and synthesis of fluorine-18 labeled matrix metalloproteinase inhibitors for cancer imaging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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