Abstract
Matrix metalloproteinases (MMPs) are key enzymes involved in cancer invasion and metastasis. New 18F-labeled MMP inhibitors (1a-c) has been designed and synthesized for cancer imaging by positron emmision tomography. The precursors were synthesized in four steps starting from D-form of amino acids. Radiosynthesis of 1a-c were carried out by simple one-pot synthesis. The resulting radiofluorinated MMP inhibitors were obtained in overall radiochemical yields of 13-43% (EOB, decay corrected) within 60-70 min (including final preparative HPLC separation).
Original language | English |
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Pages (from-to) | 975-986 |
Number of pages | 12 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 45 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2002 Oct 15 |
Keywords
- Fluorine-18
- Inhibitor
- Matrix metalloproteinase
- Pet
- Tumor imaging
ASJC Scopus subject areas
- Analytical Chemistry
- Drug Discovery
- Organic Chemistry
- Clinical Biochemistry
- Molecular Medicine
- Pharmacology