Design and synthesis of a water-soluble taxol analogue: Taxol-sialyl conjugate

Takashi Takahashi, Hirokazu Tsukamoto, Haruo Yamada

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Glycosidation, using the methylthio derivative of N-acetylneuraminic acid 3, of linker alcohol 4 in DME with 'long-range participation' produced the α-glycosyl linkage with high stereoselectivity. The α-linked sialic acid 2 was introduced in taxol without protection of the alcohol functionality in sialic acid.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number1
DOIs
Publication statusPublished - 1998 Jan 6

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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