Huge Disasters such as big earthquakes, tsunamis, typhoons and eruptions occur all over the world, so system for disaster prevention is expected. Especially, tsunamis by big earthquake cause serious damage. We propose an evacuation guidance support using multi-UAVs and aim to decrease the damage by tsunamis. Specifically, software agent decide the safest evacuation guidance route for UAVs based on the disaster situations, the elevation of evacuation route and the distance from the route to coastline etc. In addition, the agent changes the route flexibly according to the disaster situation while evacuation guidance. Also, we aim to perform evacuation guidance support effectively by the function of efficient evacuation guidance and helping for the UAV that cannot work, that is realized by cooperation of multi-UAVs. In this paper, we describe the approach to decide the evacuation guidance route for UAV and change the route flexibly. In addition, we describe the function of cooperation of multi-UAVs. We performed experiments on path re-planning according to disaster situation in simulation and flight of UAV in real world to confirm the effectiveness of our approach.