Design and function of amylose-poly(L-lysine) conjugate nanogels

Junko Tamada, Mio Yamazaki, Nobuyuki Morimoto, Longliang Wu, Kaoru Takada, Sung Won Choi, Atsushi Maruyama, Kazunari Akiyosh

Research output: Contribution to conferencePaperpeer-review

Abstract

Poly(L-lysine) (PLL) can interact with DNA and forms stable polyion complex (PIC). Novel amylose primers those consist of maltopentaose (MP) and PLL or cholesteryl PLL were designed. 30% of MP substituted PLL (MaPLL, CH-MaPLL) were synthesized by reductive animation reaction. The MP-PLL and CH-MaPLL copolymers were enzymatically polymerized and the degree of polymerization (DP) was linearly increased in accordance to the polymerization time. Positive charge of the conjugates was shielded with increasing the degree of polymerization. Interaction of the conjugates with DNA was investigated.

Original languageEnglish
Pages4808
Number of pages1
Publication statusPublished - 2006
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Keywords

  • Amylose
  • Enzymatic polymerization
  • Nucleic chaperone
  • Poly(l-lysine)

ASJC Scopus subject areas

  • Engineering(all)

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