Design and application of ion-channel sensors based on biological and artificial receptors

Masao Sugawara, Ayumi Hirano, Philippe Bühlmann, Yoshio Umezawa

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)


This paper reviews approaches to chemical sensing with receptor-modified electrodes that mimic the function of natural membranes containing biological and synthetic receptor channels. We highlight different types of ion-channel sensors, focusing on the working principle and the fundamental aspects, such as sensitivity and selectivity. It is demonstrated that biological receptors such as glutamate receptor ion channels and gramicidin, embedded in bilayer lipid membranes, have the potential as sensing elements for ion channel sensors with excellent sensitivity and selectivity. In addition, higher selectivities by improved receptor desigh, taking into account the particular advantages of interfacial analyte recognition at LB membranes and SAMs, are also shown with ion-channel sensors for antibodies, protamine, heparin, abasic DNA sites, and oligonucleotides.

Original languageEnglish
Pages (from-to)187-201
Number of pages15
JournalBulletin of the Chemical Society of Japan
Issue number2
Publication statusPublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)


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