Descriptors of Malignant Non-mass Enhancement of Breast MRI: Their Correlation to the Presence of Invasion

Youichi Machida, Akiko Shimauchi, Mitsuhiro Tozaki, Yoshifumi Kuroki, Tamiko Yoshida, Eisuke Fukuma

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Rationale and Objectives: This study aims to investigate the clinical significance of malignant non-mass enhancement (NME) descriptors in breast magnetic resonance images by assessing their correlation to the presence of invasion or lymph node metastasis. Materials and Methods: Three radiologists independently reviewed magnetic resonance images with malignant NMEs between January 2008 and December 2009. Distribution was assessed first, and then each of four internal enhancement patterns-clumped, clustered ring, branching, and hypointense area-was evaluated dichotomously (yes or no). Because clustered rings and hypointense areas were thought to be major structural elements of heterogeneous NMEs, they were also evaluated by integrating them into one collective descriptor we called the "heterogeneous structures." Chi-square test, Fisher exact test, or Student t test was used to analyze differences of variables by each reviewer. Positive predictive values (PPVs) of descriptors in predicting presence of invasion or lymph node metastasis were calculated. P < 0.05 was considered significant. Results: We included 131 malignant NMEs (76 in situ and 55 invasive) in 129 patients (two bilateral). All three observers' results showed clustered rings (PPVs 54.5%, 54.5%, 50.0%) (P = 0.0005, 0.038, 0.029) and hypointense areas (PPVs 63.6%, 61.5%, 73.9%) (P = 0.004, 0.024, 0.0006) to be significantly associated with invasion. When clustered rings and hypointense areas were integrated into heterogeneous structures, they were significantly associated with invasion (PPVs 54.3%, 53.3%, 51.8%) (P = 0.0003, 0.016, 0.003). Conclusions: The NME descriptors clustered rings, hypoechoic areas, and heterogeneous structures, assessed collectively, were associated with invasive breast cancer.

Original languageEnglish
Pages (from-to)687-695
Number of pages9
JournalAcademic radiology
Issue number6
Publication statusPublished - 2016 Jun 1


  • Breast
  • Descriptor
  • Invasive breast cancer
  • Magnetic resonance imaging
  • Non-mass enhancement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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