Deprotonative metalation using ate compounds: Synergy, synthesis, and structure building

Robert E. Mulvey, Florence Mongin, Masanobu Uchiyama, Yoshinori Kondo

Research output: Contribution to journalReview article

402 Citations (Scopus)

Abstract

Historically, single-metal organometallic species such as organolithium compounds have been the reagents of choice in synthetic organic chemistry for performing deprotonation reactions. Over the past few years, a complementary new class of metalating agents has started to emerge. Owing to a variable central metal (magnesium, zinc, or aluminum), variable ligands (both in their nature and number), and a variable second metallic center (an alkali metal such as lithium or sodium), "ate" complexes are highly versatile bases that exhibit a synergic chemistry which cannot be replicated by the homometallic magnesium, zinc, or aluminum compounds on their own. Deprotonation accomplished by using these organometallic ate complexes has opened up new perspectives in organic chemistry with unprecedented reactivities and sometimes unusual and unpredictable regioselectivities.

Original languageEnglish
Pages (from-to)3802-3824
Number of pages23
JournalAngewandte Chemie - International Edition
Volume46
Issue number21
DOIs
Publication statusPublished - 2007 Jun 27

Keywords

  • Ate complexes
  • Dimetallic complexes
  • Inverse crown compounds
  • Metalation
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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