Deprotonative C-H silylation of functionalized arenes and heteroarenes using trifluoromethyltrialkylsilane with fluoride

Midori Sasaki, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A highly selective C-H silylation reaction of functionalized arenes and heteroarenes was developed using Ruppert-Prakash reagent (TMSCF3) activated by alkali metal fluoride. TMSCF3 is considered to play dual roles as a precursor of a mild base and also as a silicon electrophile. The silylation is compatible with sensitive functional groups such as halogen and nitro groups.

Original languageEnglish
Pages (from-to)848-851
Number of pages4
JournalOrganic letters
Volume17
Issue number4
DOIs
Publication statusPublished - 2015 Feb 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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