Depressor mechanism of enalapril in rats made hypertensive by norepinephrine or vasopressin

M. Yasujima, K. Abe, M. Tanno, M. Kanazawa, K. Yoshida, M. Sato, K. Takeuchi, K. Yoshinaga

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We evaluated the antihypertensive mechanism of enalapril, a long-lasting inhibitor of angiotensin-converting enzyme, in rats made hypertensive by chronic infusion of norepinephrine or vasopressin. The hypertensive effect of norepinephrine (1.8 mg/kg/day intraperitoneal (i.p.)) or vasopressin (7.2 U/kg/day i.p) was completely abolished by simultaneous administration of enalapril (6 mg/kg/day i.p.). The antihypertensive effect of enalapril was not reversed by simultaneous administration of subpressor doses of angiotensin II (36 and 100 μg/kg/day i.p). However, the hypertensive effects of angiotensin II at pressor doses (600 and 900 μg/kg/day i.p.) in enalapril-infused rats were not different from those in vehicle-infused rats. These results indicate that the hypotensive effect of enalapril may in part depend on a reduced sensitivity of the vasculature to norepinephrine and vasopressin, independent of inhibition of angiotensin II formation.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNephron
Volume55
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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